STEMM Pharma

Understand new indications in the context of specific product strategy

Advise planning for primary research, such as choice of patient-reported outcome instruments and comparators

Estimate clinical comparisons of products versus competitors

Capitalize on existing research while assessing evidence gaps

Provide information for value development planning

Identify and prioritise the most fitting and attractive biological targets for a technology platform of interest

Define and refine research questions as they pertain to the SLR objectives

Design of search strings and algorithms to be implemented in scientific literature databases (PubMed, EMBASE, Cochrane, etc.) and grey literature

Develop inclusion/exclusion criteria within the PICOS framework 

Synthesise and evaluate the evidence necessary in a timely and strategic manner to maximise the commercial value of product(s) by demonstrating product differentiation and economic value.

Develop and execute advanced analytic methods in the assessment of real-world evidence and insights

Generate evidence-based therapeutic guidelines

Participate in non-literature-based research and consulting activities within stakeholders 

Evaluate the current state, future scenarios and opportunities of an indication or therapeutic area of interest 

Conduct laboratory research related to drug efficacy and development of formulations suitable for pre-clinical use 

Support preclinical drug delivery platforms and efficacy studies related to animal disease models

Work with external collaborators and Contract Research Organisations for timely execution of projects.

Draft new project proposals for internal R&D and extramural funding.

Conduct multiparametric analyses to identify druggable pathways and mechanism-based targets of disease 

Utilise in silico approaches to identify molecules for drug repurposing

Design experimental verification to leverage key drug discovery and development insights

Coordinate pre-clinical studies and, where possible, translational and clinical trials 

Provide regulatory guidance,  related to repurposed drugs and combination products.

Conduct domain-specific and Bayesian modelling and simulation to support biomedical decision making

Apply models to support decision-making through Monte-Carlo simulation

Perform model-based meta-analysis of therapeutic area summary-level data

Conduct MBMA analyses to address client’s key drug development questions

Design and execute quantitative research such as economic evaluations, cost-effectiveness analyses, budget impact models, comparative effectiveness tests